At the frontier of neuroimmunology, this lab investigates how immune cells shape brain health and disease. We focus on uncovering the roles of diverse immune populations — including microglia, border-associated macrophages, and antigen-presenting cells — in maintaining central nervous system (CNS) integrity and driving neurodegenerative pathologies. Using innovative mouse models and integrative, cutting-edge approaches, our goal is to redefine the immune landscape of the brain and brain border.
Research interests
Immune cell infiltration into the CNS
Immune cell infiltration into the CNS
We study the mechanisms that allow peripheral immune cells – particularly monocytes and lymphocytes – to infiltrate the CNS.
Please click “more” for details
Macrophages roles for BBB development and homeostasis
Macrophages roles for BBB development and homeostasis
Using advanced genetic tools, we study border-associated macrophages (BAMs) and their critical functions during CNS vascular development.
Please click “more” for details
MHC class II possitive cells in the CNS
MHC II+ cells in the CNS
We investigate the poorly understood population of MHC class II-expressing cells located in the CNS border.
Please click “more” for details